Publication Highlights
2009 2008 2007 2006 2005 2004 2003 2002 2001 2000
Gammon ST, Villalobos VM, Roshal M, Samrakandi M, Piwnica-Worms D. Rational design of novel red-shifted BRET pairs: platforms for real-time single chain protease biosensors. Biotechnol Prog 2009 25(2): 559-69.
|
PubMed Link |
Gross S, Gammon ST, Moss BL, Rauch D, Harding J, Heinecke JW, Ratner L, Piwnica-Worms D. Bioluminescence imaging of myeloperoxidase actvity in vivo. Nat Med 2009 15(4): 455-61. |
PubMed Link |
Yang KS, Ilagan MX, Piwnica-Worms D, Pike LJ. Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor. J Biol Chem 2009; 284(12): 7474-82. |
PubMed Link |
Dothager RS, Flentie KN, Moss BL, Pan D, Kesarwala AH, Piwnica-Worms D. Advances in bioluminescence imaging of live animal models. Curr Opin Biotechnol 2009; 20(1): 45-53.
|
PubMed Link |
Pichler A, Prior JL, Luker GD, Piwnica-Worms D. Generation of a highly-inducible Gal4→Fluc universal reporter mouse for in vivo bioluminescence imaging. Proc Natl Acad Sci USA 2008; 105(41): 15932-7. |
PubMed Link |
Moss BL, Gross S, Gammon ST, Vinjamoori A, Piwnica-Worms D. Identification of a ligand-induced transient refractory period in nuclear factor-kappaB signaling. J Biol Chem 2008; 283(13): 8687-98. |
PubMed Link |
Naik S, Piwnica-Worms D. Real-time imaging of beta-catenin dynamics in cells and living mice. Proc Natl Acad Sci USA 2007; 104(44): 17465-70. |
PubMed Link |
Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms DR, Ley TJ. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity 2007; 27(4): 635-46. |
PubMed Link |
Villalobos V, Naik S, Piwnica-Worms D. Current state of imaging protein-protein interactions in vivo with genetically encoded reporters. Ann Rev Biomed Engineering 2007; 9: 321-49. |
PubMed Link |
Johnson JR, Fu N, Arunkumar E, Leevy WM, Gammon ST, Piwnica-Worms D, Smith BD. Squaraine rotaxanes: superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging. Angew Chem Int Ed 2007, 46(29): 5528-31. |
PubMed Link |
Gross S, Abraham U, Prior JL, Herzog ED, Piwnica-Worms D. Continuous delivery of D-luciferin by implanted micro-osmotic pumps enables true real-time bioluminescence imaging of luciferase activity in vivo. Molec Imaging 2007; 6(2): 121-30. |
PubMed Link |
Bullok KE, Maxwell D, Kesarwala AH, Gammon S, Prior JL, Snow M, Stanley S, Piwnica-Worms D. Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. Biochemistry 2007; 46(13): 4055-65. |
PubMed Link |
Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci USA 2007; 104(13): 5680-5. |
PubMed Link |
Gammon ST, Leevy WM, Gross S, Gokel GW, Piwnica-Worms D. Spectral unmixing of multicolored bioluminescence emitted from heterogeneous biological sources. Anal Chem 2006; 78(5): 1520-7. |
PubMed Link |
Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn, MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DH. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-w deposition in an Alzheimer's disease mouse model. J Clin Invest 2005; 115(11): 3285-90. |
PubMed Link |
Gross S, Piwnica-Worms D. Real-time imaging of ligand-induced IKK activation in intact cells and in living mice. Nat Methods 2005; 2(8): 607-14. |
PubMed Link |
Gross S, Piwnica-Worms D. Spying on cancer: molecular imaging in vivo with genetically encoded reporters. Cancer Cell 2005; 7(1): 5-15. |
PubMed Link |
Luker KE, Smith MC, Luker GD, Gammon ST, Piwnica-Worms H, Piwnica-Worms D. Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci USA 2004; 101(33): 12288-93. |
PubMed Link |
Pichler A, Prior JL, Piwnica-Worms D. Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc Natl Acad Sci USA 2004 101(6): 1702-07. |
PubMed Link |
Luker GD, Pica CM, Song J, Luker KE, Piwnica-Worms D. Imaging 26S proteasome activity and inhibition in living mice. Nat Med 2003 9(7): 969-73. |
PubMed Link |
Cao X, Leonard K, Collins LI, Cai SF, Mayer JC, Payton JE, Walter MJ, Piwnica-Worms D, Schreiber RD, Ley TJ. Interleukin 12 Stimulates IFN-{gamma}-Mediated Inhibition of Tumor-Induced Regulatory T-Cell Proliferation and Enhances Tumor Clearance. Cancer Res 2009; in press.
|
|
Jost SC, Collins L, Travers S, Piwnica-Worms D, Garbow JR. Measuring brain tumor growth: combined bioluminescence imaging-magnetic resonance imaging strategy. Mol Imaging 2009; 8(5): 245-53.
|
|
Dothager RS, Piwnica-Worms D. Molecular imaging of pulmonary disease in vivo. Proc Am Thorac Soc 2009; 6(5): 403-10. |
|
Nervi B, Ramirez P, Rettig MP, Uy GL, Holt MS, Ritchey JK, Prior JL, Piwnica-Worms D, Bridger G, Ley TL, DiPersio JF. Chemosensitization of AML following mobilization by the CXCR4 antagonist AMD3100. Blood 2009; 113(21): 5340-51. |
|
Barnett EM, Zhang X, Maxwell D, Chang Q, Piwnica-Worms D. Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model. Proc Natl Acad Sci USA 2009; 106(23): 9391-6. |
|
Carreno BM, Garbow JR, Kolar GR, Jackson EN, Engelbach JA, Becker-Hapak M, Carayannopoulos LN, Piwnica-Worms D, Linette GP. Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastases. Clin Cancer Res 2009; 15(10): 3277-86. |
|
Capoccia BJ, Robson DL, Levac KD, Maxwell DJ, Hohm SA, Neelamkavil MJ, Bell GI, Xenocostas A, Link DC, Piwnica-Worms D, Nolta JA, Hess DA. Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity. Blood 2009; 113(21): 5340-51.
|
|
McDunn JE, Muenzer JT, Dunne B, Zhou A, Yuan K, Hoekzema A, Hilliard C, Chang KC, Davis CG, McDonough J, Hunt C, Grigsby P, Piwnica-Worms D, Hotchkiss RS. An anti-apoptotic peptide improves survival in lethal total body irradiation. Biochem Biophys Res Commun 2009; 382(4): 657-62.
|
|
Hirbe AC, Roelofs AJ, Floyd DH, Deng H, Becker SN, Lanigan LG, Apicelli AJ, Xu Z, Prior JL, Eagleton MC, Piwnica-Worms D, Rogers MJ, Weilbaecher K. The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts. Bone 2009; 44(5): 908-16. |
|
Ju JS, Miller SE, Jackson E, Cadwell K, Piwnica-Worms D, Weihl CC. Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters. Autophagy 2009; 5(4): 511-9.
|
|
Maxwell D, Chang Q, Zhang X, Barnett EM, Piwnica-Worms D. An Improved Cell-Penetrating, Caspase-Activatable, Near-Infrared Fluorescent Peptide for Apoptosis Imaging. Bioconjug Chem 2009 20(4): 702-9.
|
|
Gammon ST, Villalobos VM, Roshal M, Samrakandi M, Piwnica-Worms D. Rational design of novel red-shifted BRET pairs: platforms for real-time single chain protease biosensors. Biotechnol Prog 2009 25(2): 559-69.
|
|
Gross S, Gammon ST, Moss BL, Rauch D, Harding J, Heinecke JW, Ratner L, Piwnica-Worms D. Bioluminescence imaging of myeloperoxidase actvity in vivo. Nat Med 2009 15(4): 455-61.
|
|
Uluçkan O, Becker SN, Deng H, Zou W, Prior JL, Piwnica-Worms D, Frazier WA, Weilbaicher KN. CD47 Regulates Bone Mass and Tumor Metastasis to Bone. Cancer Res 2009; 69(7): 3196-3204.
|
|
Yang KS, Ilagan MX, Piwnica-Worms D, Pike LJ. Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor. J Biol Chem 2009; 284(12): 7474-82. |
|
Dothager RS, Flentie KN, Moss BL, Pan D, Kesarwala AH, Piwnica-Worms D. Advances in bioluminescence imaging of live animal models. Curr Opin Biotechnol 2009; 20(1): 45-53.
|
|
Rauch D, Gross S, Harding J, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L. Imaging spontaneous tumorigenesis: Inflammation precedes development of peripheral NK tumors. Blood 2009; 113(7): 1493-500. |
|
Kesarwala AH, Samrakandi MM, Piwnica-Worms D. Proteasome inhibition blocks ligand-induced dynamic processing and internalization of EGFR via altered receptor ubiquitination and phosphorylation. Cancer Res 2009; 69(3): 976-83. |
|
Pazolli E, Luo X, Brehm S, Carbery K, Chang JJ, Prior JL, Doherty J, Demehri S, Salavaggione L, Piwnica-Worms D, Stewart SA. Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res 2009; 69(3): 1230-9. |
|
Parry JJ, Sharma V, Andrews R, Moros EG, Piwnica-Worms D, Rogers BE. PET imaging of heat-inducible suicide gene expression in mice bearing head and neck squamous cell carcinoma xenografts. Cancer Gene Ther 2009; 16(2): 161-70.
|
|
Goldhoff P, Warrington NM, Limbrick DD Jr, Hope A, Woerner BM, Jackson E, Perry A, Piwnica-Worms D, Rubin JB. Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. Clin Cancer Res 2008; 14(23): 7717-25.
|
|
Pichler A, Prior JL, Luker GD, Piwnica-Worms D. Generation of a highly-inducible Gal4→Fluc universal reporter mouse for in vivo bioluminescence imaging. Proc Natl Acad Sci USA 2008; 105(41): 15932-7.
|
|
Naik S, Moss BL, Pichler-Wallace A, Piwnica-Worms D. Imaging cellular networks and protein-protein interactions in vivo. In: Molecular Imaging in Oncology. Pomper M, Gelovani JT (Ed.), Informa Healthcare USA, New York, NY, 2008; in press. |
|
Flentie KN, Qi M, Gammon ST, Razia Y, Lui F, Marpegan L, Manglik A, Piwnica-Worms D, McKinney JS. Stably Integrated luxCDABE for Assessment of Salmonellae Invasion Kinetics. Mol Imaging 2008; 7(5): 222-33.
|
|
Uluçkan O, Eagleton MC, Floyd DH, Morgan EA, Hirbe AC, Kramer M, Dowland N, Prior JL, Piwnica-Worms D, Jeong SS, Chen R, Weilbaecher K. APT102, a novel ADPase, cooperates with aspirin to disrupt bone metastasis in mice. J Cell Biochem 2008; 104(4): 1311-23.
|
|
Moss BL, Gross S, Gammon ST, Vinjamoori A, Piwnica-Worms D. Identification of a ligand-induced transient refractory period in nuclear factor-kappaB signaling. J Biol Chem 2008; 283(13): 8687-98.
|
|
Leevy WM, Gammon, ST, Johnson JR, Lampkins AJ, Jiang H, Marquez M, Piwnica-Worms D, Smith BD. Non-invasive optical imaging of Staphylococcus aureus bacterial infection in living mice using a bis-dipicolylamine-zinc(II) affinity group conjugated to a near infrared fluorophor. Bioconjug Chem 2008; 19(3): 686-92. |
|
McDunn JE, Muenzer JT, Rachdi L, Chang KC, Davis CG, Dunne WM, Piwnica-Worms D, Bernal-Mizrachi E, Hotchkiss RS. Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis. Fed Assoc Soc Exper Biol J 2008; 22(2): 561-8. |
|
Maxwell DJ, Bonde J, Hess DA, Hohm SA, Lahey R, Creer MH, Piwnica-Worms D, Nolta JA. Fluorophore-conjugated iron oxide nanoparticle labeling and analysis of engrafting human hematopoietic stem cells. Stem Cells 2008; 26(2): 517-24. |
|
Zhao L, Kroenke CD, Song J, Piwnica-Worms D, Ackerman JJ, Neil JJ. Intracellular water-specific MR of microbead-adherent cells: the HeLa cell intracellular water exchange lifetime. NMR Biomed 2008; 21(2): 159-64. |
|
Zhao L, Sukstanskii AL, Kroenke CD, Song J, Piwnica-Worms D, Ackerman JJ, Neil JJ. Intracellular water specific MR of microbead-adherent cells: HeLa cell intracellular water diffusion. Magn Reson Med 2008; 59(1): 79-84. |
|
Villalobos V, Naik S, Piwnica-Worms D. Detection of protein-protein interactions in live cells and animals with split Firefly luciferase protein fragment complementation. In: Methods in Molecular Biology, Vol 439: Genomics Protocols, 2nd Edition. Starkey M, Elaswarapu R. (Ed.), Humana Press, Totowa, NJ, 2008; pp. 339-52. |
|
Cheng KT, Piwnica-Worms D. Ac-rkkrrqrrrGK(QSY21)DEVDAPC(Alexa Fluor 647)-NH2. TCAPQ647. In: Molecular Imaging and Contrast Agent Database (MICAD) [database online]. National Library of Medicine (US), NCBI, Bethesda, MD, 2008; Available from: http://micad.nih.gov.
|
|
Gross S, Moss BL, Piwnica-Worms D. Veni, vidi, vici: in vivo molecular imaging of immune response. Immunity 2007; 27(4):533-8. |
|
Piwnica-Worms, D. Spying on signal transduction and protein interactions. In: Molecular Imaging Gateway. Society of Nuclear Medicine MICoE, 2007. |
|
Pichler A, Piwnica-Worms D. Overview of Cardiovascular Molecular Imaging. In: Cardiovascular Molecular Imaging. Gropler RJ, Glover DK, Sinusas AJ, Taegtmeyer H (Ed.), Informa Healthcare USA, New York, NY, 2007, pp 1-8. |
|
Naik S, Piwnica-Worms D. Real-time imaging of beta-catenin dynamics in cells and living mice. Proc Natl Acad Sci USA 2007; 104(44): 17465-70. |
|
Gammon ST, Bernstein M, Schuster DP, Piwnica-Worms D. A method for quantification of nucleotides and nucleotide analogues in thymidine kinase assays utilizing lanthanum phosphate co-precipitation. Anal Biochem 2007; 369(1): 80-6. |
|
Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms DR, Ley TJ. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity 2007; 27(4): 635-46. |
|
Harpstrite SE, Prior JL, Rath NP, Sharma V. Metalloprobes: Synthesis, characterization, and potency of a novel gallium(III) complex in human epidermal carcinoma cells. J Inorg Biochem 2007; 101(10): 1347-53.
|
|
Hirbe A, Rubin J, Uluçkan O, Morgan E, Eagleton M, Prior J, Piwnica-Worms D, Weilbaecher K. Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone. Proc Natl Acad Sci USA 2007; 104(35): 14062-7. |
|
Villalobos V, Naik S, Piwnica-Worms D. Current state of imaging protein-protein interactions in vivo with genetically encoded reporters. Ann Rev Biomed Engineering 2007; 9: 321-49. |
|
Johnson JR, Fu N, Arunkumar E, Leevy WM, Gammon ST, Piwnica-Worms D, Smith BD. Squaraine rotaxanes: superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging. Angew Chem Int Ed 2007, 46(29): 5528-31. |
|
Nervi B, Rettig MP, Ritchey JK, Wang HL, Bauer G, Walker J, Herrbrich PE, Bonyhadi ML, Berenson RJ, Prior JL, Piwnica-Worms D, Nolta JA, DiPersio JF. Naive and ex vivo activated human T cells generate consistent engraftment and lethal graft-versus-host disease in NOD SCID b2m null mice: a novel xenogeneic GVHD model. Exper Hematol 2007; 35(12): 1823-38. |
|
Kashiwagi H, McDunn JE, Goedegebuure PS, Gaffney MC, Chang K, Trinkaus K, Piwnica-Worms D, Hotchkiss RS, Hawkins WG. TAT-Bim induces extensive apoptosis in cancer cells. Ann Surg Oncol 2007; 14(5): 1763-17. |
|
Yuan L, Siegel M, Choi K, Khosla C, Miller CR, Jackson EN, Piwnica-Worms D, Rich KM. Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene 2007; 26(18): 2563-73. |
|
Hirbe AC, Uluçkan O, Morgan EA, Eagleton MC, Prior JL, Piwnica-Worms D, Trinkaus K, Apicelli A, Weilbaecher K. Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner. Blood 2007; 109(8): 3424-31. |
|
Gross S, Abraham U, Prior JL, Herzog ED, Piwnica-Worms D. Continuous delivery of D-luciferin by implanted micro-osmotic pumps enables true real-time bioluminescence imaging of luciferase activity in vivo. Molec Imaging 2007; 6(2): 121-30. |
|
Bullok KE, Maxwell D, Kesarwala AH, Gammon S, Prior JL, Snow M, Stanley S, Piwnica-Worms D. Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. Biochemistry 2007; 46(13): 4055-65. |
|
Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci USA 2007; 104(13): 5680-5. |
|
Saxena MT, Aton SJ, Hildebolt C, Prior JL, Abraham U, Piwnica-Worms D, Herzog ED. Bioluminescence imaging of Period 1 gene expression in utero. Molec Imaging 2007; 6(1): 68-72. |
|
Yang L, Jackson E, Woerner BM, Perry A, Piwnica-Worms D, Rubin JB. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res 2007; 67(2): 651-8. |
|
Leevy WM, Gammon ST, Jiang H, Johnson JR, Maxwell DJ, Jackson EN, Marquez M, Piwnica-Worms D, Smith BD. Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe. J Am Chem Soc 2006; 128(51): 16476-7. |
|
Piwnica-Worms D, Kesarwala AH, Pichler A, Prior JL, Sharma V. Single photon emission computed tomography and psotron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease. In: Neuroimaging Clinics of North America: Molecular Neuroimaging. Schellingerhout D (Ed.), Elsevier, Philadelphia, PA, 2006; 16(4): 575-89. |
|
Kesarwala AH, Prior JL, Sun J, Harpstrite SE, Sharma V, Piwnica-Worms D. Second-generation triple reporter for bioluminescence, microPET, and fluorescence imaging. Molec Imaging 2006; 5(4):465-74. |
|
Ippolito JE, Merritt ME, Bäckhed F, Moulder KL, Mennerick S, Manchester JK, Gammon ST, Piwnica-Worms D, Gordon JI. Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers. Proc Natl Acad Sci USA 2006; 103(33): 12505-10. |
|
Gross S, Piwnica-Worms D. Molecular imaging strategies for drug discovery and development. Curr Opin Chem Biol 2006; 10(4): 334-42. |
|
Barnett EM, Elangovan B, Bullok KE, Piwnica-Worms D. Selective uptake of modified Tat peptide-fluorophore conjugates in rat retina in ex vivo and in vivo models. Invest Ophthal Visual Sci 2006; 47(6): 2589-95. |
|
Hotchkiss RS, McConnell KW, Bullok K, Davis CG, Chang KC, Schwulst S, Dunne JC, Dietz GP., Bähr M, McDunn JE, Karl IE, Coopersmith CM, Piwnica-Worms D. Tat-BH4 and Tat-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunology 2006; 176(9): 5471-7. |
|
Gammon ST, Leevy WM, Gross S, Gokel GW, Piwnica-Worms D. Spectral unmixing of multicolored bioluminescence emitted from heterogeneous biological sources. Anal Chem 2006; 78(5): 1520-7. |
|
Bullok KE, Gammon ST, Violini S, Prantner AM, Villalobos VM, Sharma V, Piwnica-Worms D. Permeation peptide conjugates for in vivo molecular imaging applications. Molec Imaging 2006; 5(1): 1-15. |
|
Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn, MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DH. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-w deposition in an Alzheimer's disease mouse model. J Clin Invest 2005; 115(11): 3285-90. |
|
Gross S, Piwnica-Worms D. Monitoring proteasome activity in cellulo and in living animals by bioluminescent imaging: technical considerations for design and use of genetically-encoded reporters. Methods Enzymol 2005; 399: 512-30. |
|
Leevy WM, Gammon ST, Levchenko T, Daranciang DD, Murillo O, Torchilin V, Piwnica-Worms D, Huettner JE, Gokel GW. Structure-activity relationships, kinetics, selectivity and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells. Organic Biomol Chem 2005; 3(19): 3544-50. |
|
Abraham U, Prior JL, Granados-Fuentes D, Piwnica-Worms DR, and Herzog ED. Independent circadian oscillations of Period1 in specific brain areas in vivo and in vitro. J Neurosci 2005; 25(31): 8620-26. |
|
Bullok K, Piwnica-Worms D. Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. J Med Chem 2005; 48(17): 5404-7. |
|
Gross S, Piwnica-Worms D. Real-time imaging of ligand-induced IKK activation in intact cells and in living mice. Nat Methods 2005; 2(8): 607-14. |
|
Pichler A, Zelcer N, Prior JL, Kuil AJ, Piwnica-Worms D. In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein. Clin Cancer Res 2005; 11(12): 4487-94. |
|
Gillies RJ, Hoffman JM, Lam KS, Menkens AE, Piwnica-Worms DR, Sullivan DC, Weissleder R. Meeting report: high-throughput technologies for in vivo imaging agents. Molec Imaging 2005; 4(2): 98-103. |
|
Sharma V, Prior JL, Belinsky MG, Kruh GD, Piwnica-Worms D. Characterization of a 67Ga/68Ga radiopharmaceutical for SPECT and PET of MDR1 P-glycoprotein transport activity in vivo: validation in multidrug resistant tumors and at the blood-brain barrier. J Nucl Med 2005; 46(2): 354-64. |
|
Bigott HM, Prior JL, Piwnica-Worms DR, Welch MJ. Imaging multidrug resistance P-glycoprotein transport function using microPET with technetium-94m-Sestamibi. Molec Imaging 2005; 4(1): 30-9. |
|
Gross S, Piwnica-Worms D. Spying on cancer: molecular imaging in vivo with genetically encoded reporters. Cancer Cell 2005; 7(1): 5-15. |
|
Sharma V, Piwnica-Worms D. Monitoring multidrug resistance P-glycoprotein drug transport activity with SPECT and PET radiopharmaceuticals. Topics Curr Chem 2005; 252: 155-78. |
|
Piwnica-Worms D, Luker KE, Villalobos VM. Molecular imaging of protein-protein interactions in living animals. In: Molecular Imaging of the Lungs. Schuster DP, Blackwell TS (Ed.), Taylor & Francis Group, LLC, Boca Raton, FL, 2005; 313-26. |
|
Piwnica-Worms D, Luker KE. Imaging protein-protein interactions in whole cells and living animals. In: Molecular Imaging - An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy. Bogdanov AA Jr, Licha K (Ed.), Ernst Schering Research Foundation, Springer-Verlag, Heidelberg, 2005; 35-41. |
|
Smith MC, Luker KE, Garbow JR, Prior JL, Jackson E, Piwnica-Worms D, Luker GD. CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res 2004; 64(23): 8604-12. |
|
Sharma V. Radiopharmaceuticals for assessment of multidrug resistance P-glycoprotein-mediated drug transport activity. Bioconjugate Chem 2004; 15(6), 1464-74. |
|
Luker KE, Smith MC, Luker GD, Gammon ST, Piwnica-Worms H, Piwnica-Worms D. Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci USA 2004; 101(33): 12288-93. |
|
Rettig MP, Ritchey JK, Prior JL, Haug JS, Piwnica-Worms D, DiPersio JF. Kinetics of in vivo elimination of suicide gene expressing T cells affects engraftment, graft-versus-host disease, and the graft-versus-leukemia effect after allogeneic bone marrow transplantation. J Immunol 2004; 173(6): 3620-30. |
|
Luker KE, Piwnica-Worms D. Optimizing luciferase protein fragment complementation for bioluminescent imaging of protein-protein interactions in live cells and animals. Methods Enzymol 2004; 385: 349-60. |
|
Piwnica-Worms D, Schuster DP, Garbow JR. Molecular imaging of host-pathogen interactions in intact small animals. Cell Microbiol 2004; 6(4): 319-31. |
|
Richard JC, Zhou Z, Chen DL, Minton MA, Piwnica-Worms D, Factor P, Ponde DE, Schuster DP. Quantification of pulmonary transgene expression with PET imaging. J Nucl Med 2004; 45(4): 644-54. |
|
Pichler A, Prior JL, Piwnica-Worms D. Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc Natl Acad Sci USA 2004 101(6): 1702-07. |
|
Schuster DP, Kovacs A, Garbow J, Piwnica-Worms D. Recent advances in imaging the lungs of intact small animals. Am J Resp Cell Molec Biol 2004; 30(2): 129-38. |
|
Zhao H, Doyle TC, Wong RJ, Cao Y, Stevenson DK, Piwnica-Worms D, Contag CH. Characterization of coelenterazine analogs for measurements of Renilla luciferase activity in live cells and living animals. Molec Imaging 2004; 3(1): 43-54. |
|
Piwnica-Worms D. Introduction to molecular imaging. J Am College Radiol 2004; 1(1 Suppl): 2-3. |
|
Prantner AM, Sharma V, Garbow JR, Piwnica-Worms D. Synthesis and characterization of a Gd-DOTA-D-permeation peptide for magnetic resonance relaxation enhancement of intracellular targets. Molec Imaging 2003; 2(4): 333-41. |
|
Luker GD, Pica CM, Song J, Luker KE, Piwnica-Worms D. Imaging 26S proteasome activity and inhibition in living mice. Nat Med 2003 9(7): 969-73. |
|
Richard JC, Zhou Z, Ponde DE, Dence CS, Factor P, Reynolds PN, Luker GD, Sharma V, Ferkol T, Piwnica-Worms D, Schuster DP. Imaging pulmonary transgene expression with positron emission tomography. Am J Respir Crit Care Med 2003; 167(9): 1257-63. |
|
| Luker GD, Sharma V, Pica CM, Prior JL, Li W, Piwnica-Worms D. Molecular imaging of protein-protein interactions: controlled expression of p53 and large T antigen fusion proteins in vivo. Cancer Res 2003; 63(8): 1780-8. |
|
|
Gammon ST, Villalobos VM, Prior JL, Sharma V, Piwnica-Worms D. Quantitative analysis of permeation peptide complexes labeled with Technetium-99m: chiral and sequence-specific effects on net cell uptake. Bioconjug Chem 2003; 14(2): 368-76. |
|
Luker GD, Sharma V, Piwnica-Worms D. Visualizing protein-protein interactions in living animals. Methods 2003; 29(1): 110-22. |
|
Ocheskey JA, Polyakov V, Harpstrite SE, Oksman A, Goldberg DE, Piwnica-Worms D, Sharma V. Synthesis, characterization, and molecular structure of a gallium(III) complex of an amine-phenol ligand with activity against chloroquine-sensitive Plasmodium falciparum strains. J Inorg Biochem 2003; 93(3-4): 265-70. |
|
Luker GD, Sharma V, Piwnica-Worms D. Noninvasive imaging of protein-protein interactions in living animals. In: Handbook of Proteomic Methods. Conn PM (Ed.), Humana Press Inc., Totowa, New Jersey, 2003; pp. 283-98. |
|
Piwnica-Worms D. Perspectives in imaging: present and future prospects of clinical molecular imaging. In: Holland-Frei Cancer Medicine e.6. Kufe, D, Pollock RE, Weichselbaum RR, Bast RC, Gansler T, Holland JF, Frei E (Ed.), B.C. Decker, Inc., Hamilton, Ontario, 2003; pp. 551-56. |
|
Piwnica-Worms D, Luker GD, Anderson C, Wahl RL. Molecular imaging in oncology. In: Molecular Nuclear Medicine: The Challenge of Genomics and Proteomics to Clinical Practice. Feinendegen LE, Shreeve WW, Eckelman WC, Bahk YW, Wagner HN Jr (Ed.), Springer-Verlag, Heidelberg, 2003; 633-651. |
|
Bullok KE, Dyszlewski M, Prior JL, Pica CM, Sharma V, Piwnica-Worms D. Characterization of novel histidine-tagged Tat-peptide complexes dual-labeled with (99m)Tc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy. Bioconjug Chem 2002; 13(6): 1226-37. |
|
Luker GD, Bardil JP, Prior JL, Pica CM, Piwnica-Worms D, Leib DA. Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice. J Virol 2002; 76(23): 12149-61. |
|
Violini S, Sharma V, Prior JL, Dyszlewski M, Piwnica-Worms D. Evidence for a plasma membrane-mediated permeability barrier to Tat basic domain in well-differentiated epithelial cells: lack of correlation with heparan sulfate. Biochemistry 2002; 41(42): 12652-61. |
|
Sharma V, Luker GD, Piwnica-Worms D. Molecular imaging of gene expression and protein function in vivo with PET and SPECT. J Magn Reson Imaging 2002; 16(4): 336-51. |
|
Luker GD, Sharma V, Pica CM, Dahlheimer JL, Li W, Ocheskey J, Ryan CE, Piwnica-Worms H, Piwnica-Worms D. Noninvasive imaging of protein-protein interactions in living animals. Proc Natl Acad Sci USA 2002; 99(10): 6961-6. |
|
Luker GD, Luker KE, Sharma V, Pica CM, Dahlheimer JL, Ocheskey J, Fahrner TJ, Milbrandt J, Piwnica-Worms D. In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1a promoter. Molec Imaging 2002; 1(2): 65-73. |
|
Dyszlewski M, Blake HM, Dahlheimer JL, Pica CM, Piwnica-Worms D. Characterization of a novel 99mTc-carbonyl complex as a functional probe of MDR1 P-glycoprotein transport activity. Molec Imaging 2002; 1(1): 24-35. |
|
Luker GD, Flagg TP, Sha Q, Luker KE, Pica CM, Nichols CG, Piwnica-Worms D. MDR1 P-glycoprotein reduces influx of substrates without affecting membrane potential. J Biol Chem 2001; 276(52): 49053-60. |
|
Luker KE, Pica CM, Schreiber RD, Piwnica-Worms D. Overexpression of IRF9 confers resistance to antimicrotubule agents in breast cancer cells. Cancer Res 2001; 61(17): 6540-7. |
|
Luker GD, Dahlheimer JL, Ostlund RE Jr, Piwnica-Worms D. Decreased hepatic accumulation and enhanced esterification of cholesterol in mice deficient in mdr1a and mdr1b P-glycoproteins. J Lipid Res 2001; 42(9): 1389-94. |
|
Slapak CA, Dahlheimer J, Piwnica-Worms D. Reversal of multidrug resistance with LY335979: functional analysis of P-glycoprotein-mediated transport activity and its modulation in vivo. J Clin Pharmacol 2001; Suppl: 29S-38S. |
|
Luker GD, Piwnica-Worms D. Beyond the genome: molecular imaging in vivo with PET and SPECT. Acad Radiol 2001; 8: 4-14. |
|
Piwnica-Worms D. Molecular imaging in the postgenomic era. Imaging Economics. CurAnt Communications, Inc., Los Angeles, 2001; 14: 12-16. |
|
Piwnica-Worms D, Luker KE, Fracasso PM. Multidrug resistance, Part A: Breast cancer. In: Nuclear Oncology. Khalkhali I, Maublant J, Goldsmith SJ (Ed.), Lippincott Williams & Wilkins, Philadelphia, 2001; 63-72. |
|
Polyakov V, Sharma V, Dahlheimer JL, Pica CM, Luker GD, Piwnica-Worms D. Novel Tat-peptide chelates for direct transduction of technetium-99m and rhenium into human cells for imaging and radiotherapy. Bioconjug Chem 2000; 11(6): 762-71. |
|
Tan B, Piwnica-Worms D, Ratner L. Multidrug resistance transporters and modulation. Curr Opin Oncol 2000; 12(5): 450-8. |
|
Chen WS, Luker KE, Dahlheimer JL, Pica CM, Luker GD, Piwnica-Worms D. Effects of MDR1 and MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on transport of (99m)Tc-tetrofosmin. Biochem Pharmacol 2000; 60(3): 413-26. |
|
Luker GD, Pica CM, Kumar AS, Covey DF, Piwnica-Worms D. Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains. Biochemistry 2000; 39(29): 7651-61. |
|
Sharma V, Beatty A, Wey SP, Dahlheimer J, Pica CM, Crankshaw CL, Bass L, Green MA, Welch MJ, Piwnica-Worms D. Novel gallium(III) complexes transported by MDR1 P-glycoprotein: potential PET imaging agents for probing P-glycoprotein-mediated transport activity in vivo. Chem Biol 2000; 7(5): 335-43. |
|
Piwnica-Worms D. Functional identification of multidrug resistance gene expression in vivo. In: American Society of Clinical Oncology Spring 2000 Educational Book. ASCO Publications and Lippincott Williams & Wilkins, Baltimore, 2000; 178-84. |
|
Piwnica-Worms D, Luker GD, Luker KE, Rao VV, Sharma V. Imaging gene expression in cancer: functional identification of multidrug resistance (MDR1) P-glycoprotein in vivo. In: Medical Radiology - Diagnostic Imaging and Radiation Oncology: Diagnostic Nuclear Medicine. Schiepers C (Ed.), Springer-Verlag, Heidelberg, 2000; 273-83. |
|
|
